Européens ou internationaux
PHC PROCORE
Date: 2024-2024
Financement: PHC PROCORE - Campus France
Porteurs du projet: Bilge Sayim & Prof. William G. Hayward de Lignan University à Hong Kong
NOSEVAC - Commission Européénne
SAVOIR - Social Sciences and Humanities Research Council of Canada (SSHRC)
Date: 2023-2027
Financeur: Social Sciences and Humanities Research Council of Canada (SSHRC)
Porteuse du projet: Amélie M. Achim
Partenaire au laboratoire: Dominique Knutsen
CAPES - COFECUB
Date: 2023-2026
Financement: CAPES - COFECUB (Comité Français d'Evaluation de la Coopération Universitaire et Scientifique avec le Brésil)
Porteur du projet: Cédrick Bonnet
PHC Aurora
Date: 2023-2025
Funding: PHC Aurora - Campus France
Coordinator: Bilge Sayim & Pr Jonas R. Kunst de l'université d'Oslo
PHC Bosphore
Date: 2023-2025
Financement: PHC BOSPHORE - Campus France
Porteur du projet: Bilge Sayim
"Compression de l'information par le cerveau visuel et signature neuronale du masquage de la redondance" en collaboration avec l'Université Sabanci à Istanbul
Bourse mobilité USA
Bourse obtenue par Solène Kalénine pour l'année 2023/2024
CAPES (Brésil)
Date: 2023-2024
Financement: CAPES (Brésil)
Porteur du projet au laboratoire: Cédrick Bonnet
Porteur du projet au Brésil: Dr. Caio Cruz
CHAIRE FRANCO BRESILIENNE
Date: 2023
Financement: 3 universités brésiliennes (USP, UNESP, UNICAMP) et le Consulat Général de France à Sao Paulo
Porteur du projet: Cédrick Bonnet
PHC Germaine de Stael
Date: 2022-2023
Financement: PHC Germaine de Stael - Campus France
Porteur du projet au laboratoire: Dominique Knutsen
Porteur de projet Suisse: M. Fossard
FAIR
Date: 2021-2024
Financement: H2020
Porteuses du projet: Partenaire: Delphine Grynberg et Christelle Duprez
Résumé du projet:
Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Antibiotics constitute the standard of care but are faced with the emergence of antimicrobial resistance (AMR) and the curative failure. The FAIR consortium aims at assessing an adjunct to antibiotic therapy as an emerging concept of overcome AMR in pneumonia. The project leverages (i) a unique immunomodulatory flagellin that enhances airway epithelial innate immune defences and increases the therapeutic outcome relative to antibiotic alone, and (ii) airway-specific aerosol delivery by nebulization.
FAIR’s objectives are to:
• develop nebulization modalities for optimal airway targeting and rapid action at the infection site
• demonstrate that nebulized flagellin strengthens the response to antibiotics in relevant preclinical models of antibioticresistant pneumonia
• identify host immune factors required for the gain of protection with systems biology
• implement pharmacokinetics/pharmacodynamics model-based design and simulation for clinical validation
• assess nebulized flagellin’s safety in a Phase I clinical trial.
• analyze the acceptability and economic relevance of the therapy
• identify stratification markers that predict the course of pneumonia and treatment in antibiotic-treated cohorts.
Expected outcomes include the enrichment of the pipeline of novel treatments against pneumonia, reinforcement of EU capacity to control AMR and infections, the Phase I safety report on nebulized flagellin, recommendations for future trials, and acceptability by the stakeholders and cost-effectiveness for public health. FAIR will develop new avenues of research on mechanisms of action of the adjunct flagellin, and will define (for future trials) the subpopulation of patients that might benefit most from this treatment. Our industrial partnerships and exploitation plan will enable straightforward development of drug and nebuliser device, and bring innovation to the patients.
VISOSCIL- Basque Center on Cognition, Brain and Language
Date: 2021-2022
Funding: Basque Center on Cognition, Brain and Language
Coordinator: Gwendoline Mahé
Maimonide
Date: 2021-2022
Financement de projet: PHC Maimonide, Campus France
Porteur du projet: Yann Coello
Composition des équipes:
France : Mme Bartolo Angela*, Professeure
M. Coello Yann*, Professeur
M. To be recruited To be recruited*, PhD
Israël : M. Fishbain Barak*, Assistant professor
Mme Givon-Benjo Nur*, Phd
Mme Okon-Singer Hadas*, Associated professor
MONUMENT
Date: 2020-2023
Financement: Interreg 2 Seas Mers Zeeën
Porteur·euse du projet: Partenaire: Emilie Wawrziczny et Pascal Antoine
CASCADE
Date: 2017-2021
Financement: Interreg 2 Mers
Porteur du projet: Partenaire: Pascal Antoine et Mohamad El Haj (Université de Nantes)