National
EN-HOPE SMART4CBT (INCA PEDIACRIEX)
Date: 2023-2028
Funding: Institut national du cancer (Appel à candidatures 2023 : labellisation de Centres de recherche intégrée d’excellence en cancérologie pédiatrique)
Coordinator: Pr Natacha Entz-Werlé (CHU de Lille)
Partner in the laboratory: Pascal Antoine, Delphine Grynberg, Kristopher Lamore, Laurine Milville
Abstract: This is an interregional collaboration (Strasbourg, Nancy, and Lille) involving various clinical and research teams from CNRS, INSERM, University of Lille, University of Lorraine, University of Strasbourg, IESEG, ICN, university hospitals, cancer care centers, as well as parent-patient associations. This connection between different teams forms a solid foundation for multidisciplinary and multisectoral research, aiming to accelerate the understanding of brain tumors and their resistance to radiotherapy. This labeling will enable this consortium to now stand as a catalyst for more effective treatment of young patients with the most aggressive tumors and to develop new support strategies for patients and families.
PhD grant (INCA)
CandyStress (INCA)
Date: 2023-2025
Funding : Institut National du Cancer
Coordinator : Christelle Duprez
Partners in the laboratory : Kristopher Lamore, Jean Louis Nandrino
Clinical center involved in the project : Centre Oscar Lambret
Abstract : Because they are confronted with the potentially traumatic aspects of a cancer diagnosis and the chronic stress associated with the various stages of treatment, cancer patients and their caregivers may be particularly at risk of developing a stress disorder over the course of their lives, and in particular cancer-related post-traumatic stress disorder (Ca-PTS). The CandyStress project aims to initiate the co-construction of a personalized support for patient-caregiver dyads at risk of Ca-PTS. The need for such a specific intervention will be assessed by 1) a quantitative screening of Ca-PTS in dyads in the year following cancer diagnosis, and 2) discussions with patients, caregivers and health practicioners on their perception of the need for such support and its components.
REPHEMO LNH (Cancéropôle Nord Ouest)
Date: 2023-2025
Funding: Cancéropole Nord Ouest
Coordinator: Christelle Duprez
Partner in the laboratory: Pascal Antoine
Clinical center involved in the project : hopital St Vincent de Paul (GHICL)
Abstract:
An interest in representations in hematology is all the more crucial as these cancers are characterized by the fact that, unlike solid tumors, active treatment is not necessarily prescribed immediately after diagnosis. These characteristics are likely to influence the way patients perceive and subsequently manage their disease and its treatment. Quantitative studies have explored representations in the context of lymphoma. There have also been a number of thematic qualitative studies of patients with haematological malignancies. These studies have adopted a cross-sectional approach. In these diseases, however, it seems interesting to see to what extent patients' representations of their disease evolve over time, during their course of care/active monitoring, etc., and to what extent they are affected by the disease. In this sense, Longitudinal Interpretative Phenomenological Analysis (LIPA) is a particularly well-suited qualitative approach to understand life situations in which the individual's experience is dynamic and can evolve over time. A complementary and particularly original methodology for understanding patients' representations of their illness is to ask them to draw their pathology as they see it. The aim of this project is 1) to explore patients' representations of their illness when faced with the recent discovery of lymphoma, and 2) to study how these representations evolve over time, during the course of their treatment.
Research chair OPSYRII (INCA)
Date: 2021-2026
Funding: INCa (French national cancer institute), in partnership with the Université de Lille, the SCALab UMR 9193 laboratory, the Centre Oscar Lambret and the ONCOLille Institute.
Recipient: Kristopher Lamore
Brief description:
This research chair aims to develop a program to improve the support provided to cancer patients and their families through the development and evaluation of interventions.
What is a research chair?
The purpose of a chair is to strengthen a research team to develop a priority research theme. To this end, financial and human resources are made available to the chairholder to enable him or her to develop projects with a strong economic and social impact, as well as to develop research, teaching, and training. This allows the development, consolidation and structuring of interactions between the academic and the socio-economic environment.
What are the objectives of the opsyrii research chair?
The general objective is to develop a research program aimed at increasing and disseminating knowledge about the adjustment processes of patients, their families, and healthcare professionals. To this end, innovative interventions will be designed and evaluated to test their effectiveness with a goal of optimizing the support offered to patients and their care pathways.
Over the last ten years, research in psycho-oncology has focused mainly on the psychological repercussions of cancer on patients and their life partners. This research has made it possible, among other things, to identify the coping strategies used by these people to cope with the disease. In addition to the couple, the family is also strongly impacted after a cancer diagnosis in one of its members. It is precisely these family interactions in cancer care that have been less explored, and yet suggest that family members can and should be better supported in this ordeal.
The projects
1. The ICEbreaker intervention: Information, communication, and emotion regulation in cancer care
2. RESIST: The announcement of the cancer progression: a communication challenge between healthcare professionals and the patient-family dyad
3. The TRANSITION intervention: Accompanying pediatric cancer survivors and their parents in the transition from pediatric to adult healthcare
See the Chair's website for more information (available from 04/10/2022)
SMARTBINGE (INCA)
Date: 2021-2025
Funding: INCA
Coordinator: Mickaël NAASSILA (UPJV)
Coordinator SCAlab: Jean Louis Nandrino
LOLEMATH (AAP PIA IDT 100% inclusion)
Funding : PIA - Pôle Pilote 100% IDT - INSPÉ de l’Académie d’Amiens – Hauts-de-France
Lolemath : Partnership scheme aimed at improving the capacities of pupils (from cycle 1 to 3) in language (speaking and reading) and in mathematics.
Date: 2022-2024
Coordinator: Sandrine Mejias
100% plus simple (AAP PIA IDT 100% inclusion)
Date: 2022-2023
Financement du projet: AAP PIA IDT 100% inclusion
Porteuse du projet: Ludivine Javourey - Drevet
ANDEMOCHIR
Date: 2019-2023
Funding: INCA (Institut National Contre le Cancer)
Coordinator: Delphine Grynberg & Guillaume Piessen (CHU de Lille)
Abstract:
Scientific background
Most esogastric (EG) cancer patients will undergo surgery. Unfortunately, despite recent medical improvements, severe post-operative morbidity is 30% and the 90-day post-operative mortality rate is about 13%. Many studies have identified medical and tumor factors predicting morbidity and mortality in these patients. However, no study has yet evaluated their role of depressive and/or anxious symptoms in the poor prognosis in EG cancer patients despite evidence of an association between these symptoms and morbimortality after cardiac surgery. Concerning the explanatory mechanisms, these affective symptoms may lead to disrupted immunological and inflammatory responses, which could account for the poor prognosis after surgery. Surprisingly, no study has yet tested this hypothesis in any surgical populations, ignoring the role of depressive and/or anxious symptoms and the associated disrupted biological responses in morbimortality after surgery. However, this issue is very relevant in EG cancer because these symptoms affect 30% of patients, making them highly vulnerable to post-operative morbimortality.
Project objectives and methodology
Using the FREGAT national clinico-biological database, which prospectively collects clinical, biological and psychological data from EG cancer patients at the main stages of their treatments, this project aims to evaluate the association between depressive and/or anxious symptoms with (1) the post-operative morbimortality for EG cancer and (2) inflammation, immune and tumor markers.
Expected results
We hypothesize that there is an association between anxious and/or depressive symptoms, post-operative morbimortality and disrupted immunological and inflammatory responses. The results will provide a better understanding of the role of affective symptoms in post-operative morbimortality and will contribute to its reduction by assessing and treating the affective symptoms at the early stages of treatment.
ERE-CHILD
CALBILEX (AAP PIA IDT 100% inclusion)
UTEP
Date: 2017-2020
Funding: Ministry of Health, PHRIP
Principal investigator: Maryline BOURGOIN, chief of the Transversal Unit of Patient Education at the Teaching Hospital of Lille
Scientific Director : Sophie LELORAIN
Although patient education (PE) programmes have been proved very efficient to help patients regarding their quality of life, biological markers and medical complications, only between 10 to 60% of patients uptake such programmes. Our aim was to identify, drawing upon the Health Belief Model, patients’ beliefs regarding PE that will predict their participation in PE.
This prospective research took place in 8 departments of the University Hospital of Lille. Collected data on 450 patients are about to be analyzed.