Date: 2021-2022

Funding: PHC Maimonide, Campus France

Coordinator: Yann Coello

France : Mme Bartolo Angela*, Professeur
M. Coello Yann*, Professeur
M. To be recruited To be recruited*, PhD
Israël : M. Fishbain Barak*, Assistant professor
Mme Givon-Benjo Nur*, Phd
Mme Okon-Singer Hadas*, Associated professor


Date: 2020-2023

ANR: Franco-Allemand 2019

Coordinator: Bilge Sayim

Abstract: Seeing is a product of a complex physical and physiological chain of events. While some isolated stages of the visual pathway are well understood, studying the direct link between the physical stimulus and perception remains one of the challenges in vision science. In humans, the activation of the retinal photoreceptor mosaic constitutes the cellular entry point of the visual signal. To isolate the single cell contribution to the overall percept is difficult, because in normal viewing, tens of thousands of photoreceptors are stimulated at any given moment. Moreover, precise experimental access is hindered by the optical imperfections and the constant movement of the eye. Recent advances in adaptive optics micro-stimulation, however, now make it possible to target single photoreceptor cells in the living retina for isolated function testing. Here, we ask in how far each individual photoreceptor contributes to the visual percept and if elemental cellular signals also instantiate perceptual elements. How does it look to see with only a single photoreceptor, and how do these elemental percepts combine and interact when stimuli are more complex? We will tackle these questions by direct mapping of highly controlled single (and multiple) cell stimulation and the subjective appearances they elicit. While the microscopic mapping between single cell stimulation and appearance is to- date entirely unknown, there is also a lack of understanding of the relation between stimulus and appearance on a macroscopic level, i.e. the more natural condition of spatially extended stimuli. One reason is that by far the largest part of vision research uses performance measures, like visual acuity or sensitivity, to study how well visual stimuli can be detected or discriminated, but not how they appear subjectively. To understand the underlying mechanisms of visual space perception, however, it is important to have a precise account of one of the central outputs of the system — visual appearance. Here, we will combine micro and macro captures of visual appearance, all the way from the single cone in the fovea to large arrays of cones in the periphery. To this end, we will develop novel procedures to accurately quantify subjective appearance and apply these methods in a number of paradigms that are known to alter stimulus appearance. By combining cutting-edge high-resolution optical stimulation techniques with novel appearance-based psychophysical methods in a large range of behavioral experiments, we aim to uncover the elemental building blocks of visual space perception.


Date: 2020-2022

ANR: Programme MRSEI (Montage de Réseaux scientifiques européens ou internationaux)

Coordinator: F. Rubellin, Université de Nantes

Partner in SCALab: Yann Coello


Date: 2019-2024

ANR: Générique 2019

Coordinator: Angèle Brunellière

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Abstract: The purpose of the project is to examine how spontaneous interactive cues conveyed during social interactions contribute to learning and knowledge co-construction. The project seeks to address the question of how communication shapes people’s mental representations, and whether people’s states of mind become increasingly similar as they interact due to linguistic representation adaptation. Even though convergence and feedback can be described as reflecting the speakers’ attempts to improve mutual comprehension, it is still unknown whether speakers adapt their linguistic representations after an interaction, that is, whether spoken human communication has a direct influence on the content and organization of such representations. This proposal, which combines psychological and neuroscience approaches, addresses the question of whether feedback, a dialogic marker used to ensure mutual comprehension, contributes to the adaptation of linguistic representations after an interaction between two speakers. It also seeks to determine whether feedback facilitates prediction in comprehension. Two types of linguistic representations will be examined. Using behavioral and electrophysiological measures, we will focus on the conceptual level of word meaning (i.e., the semantic level) and on the level of word form (i.e., phonological level). Prediction in comprehension (i.e., predicting of what the interlocutor wants to say) is seen as a key mechanism of the adaptation of mental representations. By using cutting-edge behavioral and electrophysiological measures in the context of spontaneous dialogue settings, this project will examine both the reorganization of semantic and phonological representations after the interaction and the mechanisms underlying this phenomenon and persisting after the interaction. The consortium of the project will be coordinated by a young researcher, who works on spoken-word recognition, semantic memory and the role of prediction in spoken-language comprehension by using behavioural and electrophysiological measures. Thanks to complementary skills of the consortium at the methodological and theoretical levels, the project will be based on solid scientific knowledge about cognitive models in spoken word recognition and semantic memory. It will also integrate notions such as concept sharedness in dialogue and prediction in comprehension. This fundamental research proposes a new theoretical view of spoken language communication accounting for the adaptation of linguistic representations in the short and the long term after a dialogue and it is centered on an innovative dynamic view of spoken human communication in which linguistic representations are conceptualised as flexible. It also has direct implications for education, as learning settings are typical situations in which one person attempts to modify another person’s mental representations through communication. Thanks to the novelty and the originality of project, the findings will be presented at international conferences and journals. This project will contribute to create a European network on spoken human communication and linguistic representations in the fields of psychology, linguistics, and cognitive neuroscience.


Date: 2019-2022

Funding: INCA (Institut National Contre le Cancer)

Coordinator: Delphine Grynberg & Guillaume Piessen (CHU de Lille)


Scientific background
Most esogastric (EG) cancer patients will undergo surgery. Unfortunately, despite recent medical improvements, severe post-operative morbidity is 30% and the 90-day post-operative mortality rate is about 13%. Many studies have identified medical and tumor factors predicting morbidity and mortality in these patients. However, no study has yet evaluated their role of depressive and/or anxious symptoms in the poor prognosis in EG cancer patients despite evidence of an association between these symptoms and morbimortality after cardiac surgery. Concerning the explanatory mechanisms, these affective symptoms may lead to disrupted immunological and inflammatory responses, which could account for the poor prognosis after surgery. Surprisingly, no study has yet tested this hypothesis in any surgical populations, ignoring the role of depressive and/or anxious symptoms and the associated disrupted biological responses in morbimortality after surgery. However, this issue is very relevant in EG cancer because these symptoms affect 30% of patients, making them highly vulnerable to post-operative morbimortality.

Project objectives and methodology
Using the FREGAT national clinico-biological database, which prospectively collects clinical, biological and psychological data from EG cancer patients at the main stages of their treatments, this project aims to evaluate the association between depressive and/or anxious symptoms with (1) the post-operative morbimortality for EG cancer and (2) inflammation, immune and tumor markers.

Expected results
We hypothesize that there is an association between anxious and/or depressive symptoms, post-operative morbimortality and disrupted immunological and inflammatory responses. The results will provide a better understanding of the role of affective symptoms in post-operative morbimortality and will contribute to its reduction by assessing and treating the affective symptoms at the early stages of treatment.


Date: 2017-2022

ANR: Générique 2017

Coordinator: Samuel Delpoulle (LISIC)

Partner in lab: Laurent Madelain

Abstract: Production of photorealistic images requires to use light simulation, that highlight visual noise. This noise disappears gradually as a function of the convergence rate of the computing methods, but at a very high time cost. This drawback is particularly penalizing when computing 3D images sequences.
The first aim of the PrISE-3D project is a better understanding of the perceptual mechanisms underlying the perception of image quality through the use of various sterescopic devices with various features.
For this, search procedures of visual convergence of the light simulation algorithms will be considered in the case of relief images. These thresholds will then be used to determine the automatic stopping condition of computation in each part of the images.
The second aim of this project will be to study and develop a mixed renderer (photorealistic rendering in the focus areas of the images and real time rendering in the other areas) by using the results of the perceptual thresholds . This mixed rendered will be develop for immersive environnements and by taking into account both actions and behaviour of the user and its limited field of vision, it should be possible to provide him with high fidelity experiences.


Date: 2017-2022


Coordinator: Pascal Antoine

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Abstract: Alzheimer Disease (AD) is a major public health issue with consequences for patients as well as for their caregivers and a high financial strain upon society. Attending a person with AD requires an ever-increasing amount of care. This is generally provided by the children or the spouse, who are indispensable to the AD patients’ well-being as they are best placed to identify their unique needs. As AD develops, patients require progressive and permanent mobilization. Researchers have therefore developed psychoeducational and cognitive support strategies to alleviate caregivers’ distress. These strategies help addressing problem solving issues, ‘burden’ and depressive symptoms with moderate effect-size, but often leave behind the positive aspects of the caregiver-patient relationship and a more generalised change of attitudes and behaviours in the context of caregiving. Moreover, considering the constraints to which caregivers can be subjected, existing supports cannot always fit with their objective availability and subjective readiness.
In this perspective, PACIC aims to first test the feasibility and then the comparative effectiveness of 3 web-based psychological interventions for caregivers of patients with AD. PACIC proposes (1) an innovative caregiving supports centred on well-being and acceptance combined with (2) a web-based and self-training approach.
The proposed program will comprise three different interventions strategies, which have already shown their potential in the framework of individualized support programmes and which still need to be tested in a web-based strategy: (1) mindfulness practice, (2) positive psychology and (3) acceptance and commitment approaches are evaluated as effective in conditions including mental health and chronic diseases. In PACIC, mindfulness exercises focus on formal meditation to limit painful ruminations. Positive psychology allows caregivers access to well-being opportunities directing their attention towards pleasurable experiences. Acceptance and commitment exercises aim to improve psychological flexibility and promote new adaptive ways of living as a caregiver.
The proposed web-based and self-training planned interventions will be easy to understand, and of short daily duration. Concrete implementation will be at participants’ discretion, enabling them to adjust to their caregiving, family, and/or professional priorities. This is important as caregivers are often forced to drop out of support groups due to unpredictable circumstances or to exhaustion. The proposed web-based strategy is meant to be complementary to existing ones. Moreover, given both social and territorial inequalities in access to supports and a growing number of caregivers, PACIC aims to address these shortcomings allowing to "enter the patient’s home" and provide daily life and relation-based support.
PACIC involves two main phases. Phase I explores the conditions of acceptability of this strategy with qualitative methods: thematic analysis of 30 interviews with caregivers on their motivations and expectations of such programmes, and focus groups with 20 professionals on their opinion on the acceptability among caregivers and their own attitude. Phase II will be devoted to the evaluation of the proposed intervention strategies. About 350 caregivers of patients with AD will be randomly assigned to 3 8-week groups and to a control one in which the usual information on the disease is provided to caregivers. The effects for each approach will be tested immediately after intervention and will be compared to pre-test. Effect persistence will be assessed with a follow-up at 6 months.
Our project should ultimately lead to a website for caregiver support and self-training based on the best exercises identified among the 3 approaches. In its final form, the website will allow to customizing the optimal exercise combination and usage patterns, and flexibly adapt commitment to the changing needs of each participant.


Date: 2017-2020

Funding: Ministry of Health, PHRIP


Principal investigator: Maryline BOURGOIN, chief of the Transversal Unit of Patient Education at the Teaching Hospital of Lille

Scientific Director : Sophie LELORAIN


Although patient education (PE) programmes have been proved very efficient to help patients regarding their quality of life, biological markers and medical complications, only between 10 to 60% of patients uptake such programmes. Our aim was to identify, drawing upon the Health Belief Model, patients’ beliefs regarding PE that will predict their participation in PE.

This prospective research took place in 8 departments of the University Hospital of Lille. Collected data on 450 patients are about to be analyzed.


Date: 2016-2021


Coordinator: Solène Kalénine

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Abstract: The project raises the general issue of the interrelations between perception, action, and cognition, which are viewed as a source of change. If the way people perceive and represent their environment depends on their own action repertoire, then changes in the action repertoire will entail modifications in the perception and representation of the environment. Research on action planning indicates that multiple action representations guide the execution of goal-directed actions and that competition between action representations affects action performance. In addition, similar processes underlie the actual execution of goal-directed actions on the one hand, and the perception of actions and the perception of manipulable objects on the other hand. Thus, we hypothesize that competition between action representations also affects object and action perception. Moreover, the recruitment and monitoring of action representations may evolve during lifespan development and change at a given age under the pressure of contextual and social factors. Consequently, the present project aims at identifying the mechanisms underlying competition between action representations during the perception of objects and object-directed actions. It further seeks to highlight the changes in perceptual processing that can be caused by developmental and contextual modifications in action processing.
The project considers a multi-level model of action representations and focus on three specific aims. Each aim combines the questions and methods of cognitive psychology, developmental psychology, social psychology, and neurosciences through the complementary expertise of four young researchers situated in Northern France. The first aim is to investigate the developmental, contextual, and social changes in the evocation and monitoring of gesture-level representations during object perception. Preliminary data indicate that perception of objects associated with conflicting structural and functional gestures entails a processing cost. In three behavioral studies, we will assess how this cost evolves during life span (childhood, adulthood, elderly), and how it can be moderated by object visual presentation and social variables (e.g. power). Object perception will be examined using a recently developed paradigm in virtual reality. The second aim is to test the hierarchical organization of action representations and specify how and when gesture-level and intention-level action representations participate in action understanding. In four studies, we will identify the temporal dynamics of action decoding at the behavioral and neural levels and further assess how the visual and social contexts modify those temporal dynamics. Action pictures containing gesture or intention violations have been designed to examine this issue. The third aim is to identify the neural markers of conflict between competing action representations in perception using electroencephalography. One study will focus on the conflict between competing gestures during object perception (cf. aim 1) and a second study will focus on the conflict between incongruent gesture and intention during action perception (cf. aim 2).
At the scientific level, findings will fuel theoretical models on perception, action semantics, and embodied cognition. They will further help determining specific periods of the life span during which perception is most affected by competing action representations and identifying factors that can reduce the cost of competition between action representations. At the societal level, findings will have an important impact in the domains of education, neurological rehabilitation, and technological innovations related to image creation and diffusion.





Date: 2016-2021


Coordinator: Séverine Casalis

See the project website

Abstract: The APPREL2 project aims to provide an account of the learning and development of the foreign language (FL or L2) lexicon in a schooling context. This context is characterized by the fact that L1 reading acquisition in still ongoing in children and that exposure to the L2 is quantitatively low. The project draws upon theoretical models developed in cognitive psycholinguistics: first, the well-structured models of skilled visual word recognition in bilinguals (especially, the BIA and BIA+ models, Dijkstra et al, 1998; Dijkstra et al 2002); and second, the models developed to describe the process of learning to read in monolinguals (Ehri, 2014). The project aims to test a developmental version of bilingual visual word recognition, BIA-d (Grainger et al, 2010), and to extend it by integrating a phonological component. This approach will be complemented by a language-teaching perspective that aims to connect our experimental studies to classrooms situations and to situate (visual) word recognition within a broader spectrum of emerging L2 skill and knowledge. Models of L2 lexical development (DevLex, MacWhinney) will therefore also be considered. The scientific objectives are to demonstrate how L2 words are progressively integrated in the lexicon and to analyse how L1 –L2 lexical and sublexical information interacts. We will assess how L2 word processing, especially written words, evolves according to children’s age and reading level. We also will examine orthographic processing during L2 word learning. How FL lexicon development is related to reading skills will also be explored through the impact of a partial L2 school immersion on the learning of a L3. The challenge is to trace the benefits of the early learning of two languages and the mastery of two systems of grapheme to phoneme correspondences. The project is organized into four tasks. Task 1 consists of compiling a lexical database, from textbooks, reflecting English written language instruction in secondary school. Quantitative analyses will define word lexical and sublexical characteristics, which will be used to construct assessments of L2/L3 word acquisition. The written database will be completed by transcripts of lessons. The following three tasks are organized according to participant age –leading to the use of different paradigms: word learning in primary school vs. visual -and to a lesser extend spoken- word recognition in secondary school- and the L2/L3 learning context (traditional vs. after partial immersion in L2). Task 2 aims to assess L2 word recognition development in secondary school via several experiments and will focus on L1 and L2 lexical and sublexical interactions. Task 3 is designed to investigate the effects of partial L2 immersion during L3 word processing, in terms of the development of both linguistic and word recognition skills. The aim is to assess the effects of partial immersion in L2 during L3 word processing, in terms of both linguistic development and word recognition. Task 4 uses learning experiments conducted with developing reading at primary school to assess the contribution of orthographic information in L2 word memorization. Task 4 also includes experiments in immersion programs in order to locate the benefits of the immersion situation by manipulating the L2/L3 linguistic proximity of words in word learning experiments.
The project brings researchers with expertise in reading acquisition, L2 word learning, lexical databases and language teaching. The main deliverables from the project are a lexical database for L2 English words in secondary school, dissemination papers, and concrete methodological recommendations for L2 teaching. Scientific papers will be submitted to high-impact journals and conferences, and papers will be published in professional journals to reach leading players (teachers, conseillers pédagogiques, the Inspection) in foreign language teaching in primary and secondary schools.