Funding: INCA (Institut National Contre le Cancer)
Coordinator: Delphine Grynberg & Guillaume Piessen (CHU de Lille)
Most esogastric (EG) cancer patients will undergo surgery. Unfortunately, despite recent medical improvements, severe post-operative morbidity is 30% and the 90-day post-operative mortality rate is about 13%. Many studies have identified medical and tumor factors predicting morbidity and mortality in these patients. However, no study has yet evaluated their role of depressive and/or anxious symptoms in the poor prognosis in EG cancer patients despite evidence of an association between these symptoms and morbimortality after cardiac surgery. Concerning the explanatory mechanisms, these affective symptoms may lead to disrupted immunological and inflammatory responses, which could account for the poor prognosis after surgery. Surprisingly, no study has yet tested this hypothesis in any surgical populations, ignoring the role of depressive and/or anxious symptoms and the associated disrupted biological responses in morbimortality after surgery. However, this issue is very relevant in EG cancer because these symptoms affect 30% of patients, making them highly vulnerable to post-operative morbimortality.
Project objectives and methodology
Using the FREGAT national clinico-biological database, which prospectively collects clinical, biological and psychological data from EG cancer patients at the main stages of their treatments, this project aims to evaluate the association between depressive and/or anxious symptoms with (1) the post-operative morbimortality for EG cancer and (2) inflammation, immune and tumor markers.
We hypothesize that there is an association between anxious and/or depressive symptoms, post-operative morbimortality and disrupted immunological and inflammatory responses. The results will provide a better understanding of the role of affective symptoms in post-operative morbimortality and will contribute to its reduction by assessing and treating the affective symptoms at the early stages of treatment.